Research

 

Cadasil researchWe have been researching into CADASIL for many years.  This has led to a number of significant advances including:

If you attend the CADASIL clinic at Cambridge, we are likely to ask you if you are interested in participating in our research projects.  We also keep a register of those people we see with CADASIL so that we can then notify people about future research projects.

 

References

 

1. Markus HS Martin RJ, Simpson MA, Dong YB,  Ali N,  Crosby AH, Powell JF. Diagnostic strategies in CADASIL. Neurology 2002; 59: 1134-8. Click here for PubMed abstract

 

2. Singhal S, Bevan S, Barrick T, Rich P, Markus HS. The influence of genetic and cardiovascular risk factors on the CADASIL phenotype. Brain. 2004;127:2031-8. 

 

3. Adib-Samii P, Brice G, Martin RJ, Markus HS. Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals. Stroke. 2010;41:630-4. 

 

4. O’Sullivan M, Jarosz JM, Martin RJ, Deasy N, Powell JF, Markus HS. MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology 2000; 56: 628-634. Click here for PubMed abstract

 

5. Brookes RL, Hollocks MJ, Tan RY, Morris RG, Markus HS. Brief Screening of Vascular Cognitive Impairment in Patients With Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Without Dementia. Stroke 2016;47(10):2482-7. Click here for PubMed abstract

 

6. Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat HS. Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurol. 2008;7:310-8. Click here for PubMed abstract