We share all our published genetic data usually through the International Stroke Genetics Consortium (ISGC) data portal. http://www.cerebrovascularportal.org/
Data from our specific major genetic studies is available on the links below:
WTCCC2 Ischemic Stroke Study
International Stroke Genetics Consortium (ISGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. PMC3303115
Requests for access to individual level data can be sent through the Wellcome Trust Case Control Consortium (WTCCC). Information about this can be found here.
Please note this data set is fully contained within the METASTROKE and MEGASTROKE datasets.
Traylor et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. PMC4818561
Malik et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. PMC5968830
Our first white matter hyperintensity GWAS 2016
Traylor et al. Genome-wide meta-analysis of cerebral white matter hyperintensities in stroke. PMC4731688
Our second white matter hyperintensity GWAS 2016
Traylor et al. Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).PMC3303115
Updated (2020) white matter hyperintensity and DTI GWAS
Persyn E et al. Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants. PMC7195435
The GWAS summary statistics from WMH, FA, and MD for the UK Biobank and stroke studies are available here.
We are unable to make the CHARGE available via the cerebrovascular disease portal due to dbGaP and CHARGE access regulations, and these can be obtained direct from dbGaP.